unhinged

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That is indeed the truth. But it is also the truth that, when the news broke of the Tucson shootings, no one’s first thought was that some unhinged leftist was responsible.
这个确实是真相，但真相还在于当图森市枪杀案的新闻披露之后，没有人首先想到应该由精神错乱的左派对此负责。
All this uncertainty and ignorance have left investors and entrepreneurs — the only people who can get us out of this mess — unhinged from the normal parameters with which they operate.
所有的这一切不确定性与无知已经使投资者和企业家脱离了他们正常运作所需的环境因素。唯有这些人能让我们摆脱目前这种混乱。
According to my daughter it was the earthquakes that unhinged him.
按照我女儿的说法，使他精神失常的是那地震。

And sometimes it's not good to repeat it too often; then you start to become unhinged.
有时重复太多遍也不太好;,你会开始变得神经错乱。
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The unhinged two-state solution makes Israel's legitimacy contingent on the establishment of a Palestinian state.
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The leading rebels, though inevitably a mixed bunch, make incomparably more sense than the unhinged colonel.
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If you say that someone comes or becomes unhinged, you mean that they begin to behave in an uncontrolled or unreasonable way.